Lactobacillus paracasei Has Anti-Inflammatory Effect on the Heart Failure Induced by Isoproterenol in Rats

Background: Heart Failure (HF) has become one of the most prevalent cardiovascular problems worldwide. Considering beneficial effects probiotics on human health, we aimed to investigate anti-inflammatory effect oral administration Lactobacillus paracasei in HF induced by isoproterenol. Methods: Forty Wistar male rats weighing 80g average were randomly assigned five groups eight each: control, probiotic, model, prophylaxis including probiotic + HF, and treatment (HF probiotic). The treated examined over 30 days. failure was subcutaneous injection isoproterenol (5 mg/kg) once daily for 10 At completion study, ratios Body, Heart, Left Ventricle Weights (BW, HW & LVW), serum TNF-α levels, measured ELISA, myocardial histopathological lesions determined compared among groups. Cardiac hypertrophy defined comparing LVW total body weight each animal. Results: LVW/HW ratio significantly increased with (P<0.05). In group, level lower those group. Also, infiltration inflammatory cells, necrosis, remarkably than Conclusion: study findings indicate that subsp. paracasei-8700:2 can reduce cardiac hypertrophy, inflammation rats. Therefore, results suggest a novel approach management potential prevention heart failure.